Association of the lipoprotein lipase gene polymorphisms with type 2 diabetes in Han nationality of Xinjiang
10.3760/cma.j.issn.0254-9026.2012.09.010
- VernacularTitle:脂蛋白脂酶基因多态性与新疆汉族人群2型糖尿病的关系
- Author:
Dolkun ADILA
;
Mamat TURSUN
;
Reyim ZORAGUL
;
Wupuer HAMULATI
;
Maitiyusup DOLKUN
;
Xiufen ZHENG
- Publication Type:Journal Article
- Keywords:
Diabetes mellitus,type 2;
Lipoprotein lipase;
Polymorphism,single nucleotide;
Han nationality
- From:
Chinese Journal of Geriatrics
2012;31(9):778-781
- CountryChina
- Language:Chinese
-
Abstract:
Objective To study the relationship between lipoprotein lipase (LPL) gene Hind Ⅲ and Pvu Ⅱ polymorphisms and type 2 diabetes mellitus (T2DM).Methods Polymerase chain reaction-restriction fragment length polymorphism-(PCR RFLP) technique was used to detect the genotypes of Hind Ⅲ and Pvu Ⅱ polymorphisms in the LPL gene from 110 T2DM patients and 157 healthy controls.Results The frequencies ofgenotype (H-H-,H+H-,H+H+)and allele(H,H+) of Hind Ⅲ between T2DM cases and controls showed no differences (x2 =1.998,1.262,P 0.368,0.261).There were differences in the frequency of genotype P-P-(20.9％ vs.10.8％),P+P-(40.0％ vs.58.6％),P+P+(39.1％ vs.30.6％) of PvuⅡ between T2DM and controls (x2 =10.157,P=0.006).The individuals who carried P+P genotype had an higher morbidity of T2DM than those who carried P P genotype (OR 2.833,95％CI:1.374 5.814).Conclusions The Hind Ⅲ polymorphisms in the LPL gene is not associated with T2DM risk,but the Pvu Ⅱ polymorphisms in the LPL gene is related with T2DM risk in Chinese Han population in Xinjiang,and the P+P- genotype might be a susceptible factor of T2DM.
