The effect of metformin on serum thyrotropin (TSH) in diabetic patients without thyroxin replacement GAO
- VernacularTitle:二甲双胍对糖尿病患者血清促甲状腺激素水平的影响
- Author:
Li LEI
;
Linong JI
- Publication Type:Journal Article
- Keywords:
Thyrotropin
- From:
Chinese Journal of Diabetes
2008;16(9):560-562
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the effect of metformin on thyroid hormone and thyrotropin(TSH) in diabetic patients without thyroid hormone replacement.Methods Serum levels of free T3(FT3),free T4(FT4),total T3(TT3),total T4(TT4) and TSH were measured in diabetic patients with or without metformin therapy and the relationship between TSH and metformin was analyzed.Results There were no significant differences in serum FT3(4.65±0.68 vs 4.59±0.67 pmol/L),FT4(17.88±3.26 vs 17.75±2.85pmol/L),TT3(1.79±0.42 vs 1.77±0.38nmol/L),TT4(107.9 ±22.1 vs 109.2±22.1nmol/L) and thyrotropin(ln TSH:0.49±0.83 vs 0.47±0.87 mU/L) between diabetic patients taking and not taking metformin.Conclusions In diabetic patients without thyroid hormone replacement,metformin does not suppress serum TSH
