Association of adiponectin receptor 1(Adipo R1)gene polymorphism with type 2 diabetes
- VernacularTitle:脂联素受体1基因多态性与2型糖尿病相关性研究
- Author:
Yan LIANG
;
Xiaoli YAO
- Publication Type:Journal Article
- Keywords:
Diabetes mellitus,type 2;
Gene;
Susceptibility;
Polymorphism, single nucleotide
- From:
Chinese Journal of Diabetes
2008;16(7):394-396
- CountryChina
- Language:Chinese
-
Abstract:
Objective To study the association of SNP of the AdipoR1 gene with T2DM in Xi’an population. Methods The amplification refractory mutation system(ARMS) analysis and gene sequencing were used to investigate the AdipoR1 gene polymorphism in 100 type 2 diabetics and 84 normal control subjects. Results (1) The genotype and allele frequencies of -106A/G, 5843A/G were not significantly different between type 2 diabetics and normal control subjects. (2) The diagnosis age of diabetics was significantly younger in AdipoR1 5843GG genotype group than in other genotype groups. Conclusions The data implicate that the AdipoR1 gene -106A/G and 5843A/G polymorphism may be not associated with pathogenesis of T2DM. AdipoR1 5843 GG genotype may be associated with the earlier diagnosis of T2DM
