Angiotensin Ⅱ receptor blocker induces the activation of peroxisome proliferator-activated receptor gamma
- VernacularTitle:血管紧张素Ⅱ受体阻滞剂对PPAR-γ的激活作用
- Author:
Danqing JING
;
Shinan YIN
;
Yimin MU
- Publication Type:Journal Article
- Keywords:
Peroxisome proliferation-activated receptor;
Telmisartan;
Irbesartan
- From:
Chinese Journal of Diabetes
2008;16(6):375-378
- CountryChina
- Language:Chinese
-
Abstract:
Objective To observe the effect of angiotensin Ⅱ receptor blockers(ARBs)on peroxisome proliferator-activated receptor gamma(PPAR-γ)and to explore its mechanism for improving glucose and lipids metabolism.Methods Dual-luciferase gene reporting system was used to reflect PPAR-γ promoter activation by irbesartan and telmisartan.RT-PCR was used to reflect PPAR-γ mRNA by activation of irbesartan and telmisartan.Results Irbesartan and telmisartan may increase COS-7 cells PPAR-γ promoter expression and increase 3T3-L1 cells PPAR-γ mRNA expression in dose and time-dependent manners.Conclusions ARB may activate PPARs system to play a role in improving the glucose and lipids metabolism
