Association of the serum soluble intercellular adhesion molecule-1 and soluble vascular cell adhesion molecule-1 with metabolic syndrome and its components
- VernacularTitle:血清SICAM-1、SVCAM-1表达与代谢综合征及其组分的关系
- Author:
Furong ZENG
;
Jian DU
;
Lijuan CUI
- Publication Type:Journal Article
- Keywords:
Adhesion molecule
- From:
Chinese Journal of Diabetes
2008;16(3):144-146
- CountryChina
- Language:Chinese
-
Abstract:
Objective To study the association of the serum soluble intercellular adhesion molecule-1(SICAM-1) and soluble vascular cell adhesion molecule-1(SVCAM-1) with metabolic syndrome(MS) and its components. Methods The MS was defined by criteria of the international diabetes federation. The levels of SICAM-1 ,SVCAM-1,plasma glucose,insulin,lipids,uric acid, glycosylated haemoglobin A(1C), and blood viscosity were measured. Results The concentrations of SICAM-1 and SVCAM-1 were significantly higher in subjects with MS and its components than in those without them. The concentrations of SICAM-1 and SVCAM-1 were correlated positively with disorder number of BMI, WHR, SBP, DBP,FPG, 2 hour plasma glucose, triglyceride, uric acid, HbA1c, blood viscosity and HOMA-IR,and negatively with high density lipoprotein cholesterol. Conclusions The concentrations of SICAM-1 and SVCAM-1 rise with the increase of the number of MS components. Endothelial dysfunction might participate in the occurrence and development of MS.
