Investigation of the insulin dose-correlated factors in treating patients with type 2 diabetes
- VernacularTitle:2型糖尿病胰岛素治疗剂量相关因素的探讨
- Author:
Jun YAO
;
Jia CHEN
;
Xiaohui GUO
- Publication Type:Journal Article
- Keywords:
Basal dose,bedtime insulinNPH
- From:
Chinese Journal of Diabetes
2008;16(3):163-165
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the association of insulin dose with clinical factors of type 2 diabetes. Methods We reviewed the data of 214 type 2 diabetic patients who received insulin regimens.We compared the insulin dose and period at the targeted blood glucose levels among 6 groups according to different type of oral hypoglycemic agents. Results There existed statistically significant correlations of the glucose-targeted insulin dose with course,FPG,BMI,combination therapy with oral hypoglycemic agent(P<0.1,test level P=0.1).Merely metformin failure group took less insulin than the group admitted due to combination therapy failure (P=0.016, 0.53(0.35～0.62)U/kg and 0.63(0.51～0.75)U/kg respectively).The longest targeted period existed in the later. Relationship between the targeted bedtime insulin NPH dose and FPG level can be demonstrated by equation Y=0.255X+7.8. Conclusions The targeted insulin dose is influenced by synthetic factors. Patients admitted due to combination oral hypoglycemic drug failure have the maximal targeted insulin dose and the longest titration period. The final bedtime insulinNPH dose can be predicted by FPG level.
