Expression and the related factors of E-selectin in insulin-resistant rat endothelium
- VernacularTitle:胰岛素抵抗大鼠血管内皮E-选择素的表达与相关影响因素的关系
- Author:
Chunhong SHI
;
Jianling DU
;
Guoliang LIU
- Publication Type:Journal Article
- Keywords:
Endothelium
- From:
Chinese Journal of Diabetes
2008;16(2):116-118
- CountryChina
- Language:Chinese
-
Abstract:
Objective To discuss the expression and the related factors of E-selectin in insulin-resistant(IR)rat endothelium. Methods Wistar rats were randomly divided into 3 groups: high fat feed,high fructose feed and the control feed(HF group,HG group and NC group). IR rat model was established by high fat feeding or high fructose feeding for 4 weeks and was evaluated with euglycemic clamp technique. E-selectin protein expression was detected by Western-blot analysis. Results The expression of E-selectin protein in vessel endothelium was increased in HF group and HG group compared with that in NC group (P<0.01), and higher in HF group than in HG group (P<0.05). E-selectin protein expression was correlated significantly with TG, FFA, FIns and HOMA-IR in HF group and HG group (P<0.05). Conclusions IR may cause the increased expression of E-selectin in endothelium of rats fed with high fat or fructose.
