The effects of rosiglitazone on the AT1 receptor and mRNA of spontaneously hypertensive rats(SHR)
- VernacularTitle:罗格列酮对SHR大鼠AT1受体和mRNA的影响
- Author:
Haiyan CHEN
;
Xinli WANG
;
Jian KONG
- Publication Type:Journal Article
- Keywords:
Angiotensin Ⅱreceptor 1
- From:
Chinese Journal of Diabetes
2008;16(2):119-120
- CountryChina
- Language:Chinese
-
Abstract:
To evaluate the effect of rosiglitazone on the Angiotensin Ⅱreceptor 1(AT1) and explore its mechanisms of lowering the blood pressure and protecting the organs. The spontaneously hypertensive rats(SHR) 24(SHR)rats were divided into 2 groups:12 were given rosiglitazone,12 were in the control gronp without any treatment. The duration of observation was 8 weeks. The tail blood pressure was measured indirectly.The in situ hybridization and the immunohistochemical methods were used to estimate the expression of the AT1 mRNA and AT1 receptors of heart.In rosiglitazone group,the blood pressure was reduced significantly,and the expressions of AT1 mRNA and AT1 receptor of heart were inhibited.The effect of rosiglitazone on the expressions of AT1 mRNA and AT1 receptor might be one of the reasons why insulin sensilizers reduce the blood pressure and prevent the organ injuries of hypertension.
