Effect of mycophenolic acid on the rat mesangial cell proliferation and on TGF-β and CTGF expressions induced by high glucose
- VernacularTitle:霉酚酸对高糖诱导的大鼠系膜细胞增生和高糖诱导的TGF-β、CTGF表达的影响
- Author:
Junying CHEN
;
Yongman LU
- Publication Type:Journal Article
- Keywords:
Connective tissue growth factor
- From:
Chinese Journal of Diabetes
2008;16(1):18-20
- CountryChina
- Language:Chinese
-
Abstract:
Objective To examine the effect of mycophenolic acid(MPA)on mesangial cell(MC)proliferation and on expressions of transforming growth factor-β(TGF-β)and connective tissue growth factor(CTGF)induced by high glucose.Methods The proliferation activity of mesangial cells incubated for 24h,48h and 72h in different concentrations of MPA was observed by MTT assay.The expressions of TGF-β and CTGF were measured by Western blot.Results MPA inhibited the MC proliferation and expressions of TGF-β and CTGF induced by high glucose.Conclusions MPA decreases the release of extracellular matrix by inhibiting the MC proliferation and expressions of TGF-β and CTGF,and subsequently slows the development of glomerulosclerosis in diabetic nephropathy.
