Effects of high concentration of glucose on activity and protein expression of endothelial nitric oxide synthase (eNOS) in cultured human umbilical vein endothelial cells (HUVECs)
- VernacularTitle:高浓度葡萄糖对人脐静脉内皮细胞内皮型一氧化氮合酶活性及其蛋白表达的影响
- Author:
Shenqi YANG
;
Biao XU
;
Yunhai LIU
- Publication Type:Journal Article
- Keywords:
High glucose
- From:
Chinese Journal of Diabetes
2008;16(1):50-52
- CountryChina
- Language:Chinese
-
Abstract:
The activity of eNOS was singificantly depressed by a high concentration of glucose in a concentration-and time-dependent manners after incubation of HUVECs with different concentrations of glucose and with high glucose plus insulin for different times.The physiological concentration of insulin can partially reverse the inhibitions of the activity and expression of eNOS induced by high concentration of glucose.
