Research progress in generating pancreatic β cells from pluripotent stem cells
10.3760/cma.j.issn.1673-4203.2012.10.018
- VernacularTitle:多潜能干细胞定向分化为胰腺β细胞的研究进展
- Author:
Yu ZHANG
;
Lujun SONG
- Publication Type:Journal Article
- Keywords:
Pluripotent stem cells;
Cell differentiation;
Pancreatic β-cell
- From:
International Journal of Surgery
2012;39(10):701-704
- CountryChina
- Language:Chinese
-
Abstract:
Efforts have been directed at the development of efficient protocols for the differentiation of pluripotent stem cells into pancreatic β-cells.This review focuses on the mechanism of RA,BMP,FGFs,IDE1,IDE2,ALK-i 1 and ALKI-2 during the process in which pluripotent stem cells differentiate to pancreatie β-cells and the relationship between the differentiation and the expression of the surface markers including CD14,CD49e,CD238,CD24,EpCAM,SSEA3 and SSEA1 in the different stage of this process.
