Serum changes of adiponectin, insulin resistance and their correlation in endometrial cancer patients
10.3760/cma.j.issn.0529-567x.2012.09.008
- VernacularTitle:子宫内膜癌患者血清脂联素水平与胰岛素抵抗指数的变化及相关性
- Author:
Jingran FU
;
Lina LU
;
Liping YU
;
Dongyu WANG
;
Kanshuo DING
- Publication Type:Journal Article
- Keywords:
Endometrial neoplasms;
Adiponectin;
Insulin resistance
- From:
Chinese Journal of Obstetrics and Gynecology
2012;47(9):672-675
- CountryChina
- Language:Chinese
-
Abstract:
ObjectiveTo explore changes of serum adiponectin and insulin resistance in patients with endometrial cancer and to evaluate the clinical significance and correlation.MethodsThe serum levels ofadiponectinandfastinginsulinweredeterminedbyELISA, electro-chemilluminometryand radioimmunoassay in 35 patients with endometrial cancer [ all patients divided into two groups,A1 group belonged to without postmenopausal when first visiting (n =20),A2 group belonged to postmenopausal when first visiting (n ＝ 15 ) ] and 30 cases of health control.The result of homeostasis nodel assessment-insulin resistance (HOMA-IR) index was calculated.ResultsThe levels of adiponectin in A1 group was lower than that ofhealth control group [(6.7±1.1) versus (10.0 ±1.4) ng/L,P＜0.05],and HOMA-IR was higher than that of health control group ( 3.5 ± 1.8 versus 1.1 ± 0.7,P ＜ 0.05 ).While there were not significant difference between A2 group and health control group (P ＞ 0.05 ).Adiponectin and insulin resistance was negatively correlated ( r =- 0.389,P ＜ 0.05 ).Conclusion Adiponectin reducing and insulin resistance in reproductive age patients may be the independent factors to promote endometrial cancers.
