Association of interferon-γ gene polymorphism and risk of cervical HPV infection
10.3760/cma.j.issn.0529-567x.2012.10.005
- VernacularTitle:γ干扰素基因多态性与子宫颈HPV感染的关系
- Author:
Ning WANG
;
Yanming LU
;
Shizhuo WANG
;
Qiao ZHANG
;
Qian XIAO
;
Wei LI
;
Heng WEI
;
Duo YIN
;
Ling OUYANG
;
Shulan ZHANG
- Publication Type:Journal Article
- Keywords:
Papillomavirus infections;
Cervix uteri;
Interferon type Ⅱ;
Polymorphism,single nucleotide;
Genetic predisposition to disease
- From:
Chinese Journal of Obstetrics and Gynecology
2012;47(10):738-741
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the association of interferon (IFN) γ gene polymorphisms and risk and prognosis of HPV cervical infection.Methods PCR-ASP was used for detectiug IFN-γ rs2430561 polymorphism in 179 HPV positive patients and 328 HPV negative normal controls.Results The frequency of A allele of 63.7％ (228/358) was significantly higher than the frequency of T allele of 36.3％ (130/358) in HPV positive group (P =0.045).The frequencies were 41.3％ (74/179) in AA genotype and 14.0％ (25/179) in TT genotype,women carrying AA genotype increased the risk of HPV infection compare with those with TT genotype (OR =1.784,95％ CI:1.031-3.088,P =0.039).During follow-up,the rate of HPV positive again in AA genotype was 83.8％ (62/74),while TT genotype was 20.0％ (5/25).In the analysis of Kaplan-Meier,the cumulative HPV negative rates of AA,TA and TT genotype exhibited significantly different (P =0.008).The cumulative HPV negative rate of AA genotype was the lowest (1.1％-5.9％).Conclusions IFN-γ rs2430561 polymorphisms confer the susceptibility to HPV infection.Women with AA genotype exhibited higher risk of infection and inclined to be continuous status and recurrence after HPV infection.
