The neurodegeneration of pretectal area in the early stage of diabetes
- VernacularTitle:糖尿病早期视网膜靶组织顶盖前区神经退行性病变的观察
- Author:
Yan LU
;
Shuli SHENG
- Publication Type:Journal Article
- Keywords:
Neurotrophic factor
- From:
Chinese Journal of Diabetes
2006;14(2):129-132
- CountryChina
- Language:Chinese
-
Abstract:
Objective To analyze the expression of BDNF, NGF,GFAP in Wistar rat pretectel area and determine the relation between neuron damage and neurotrophin change of pretectal area and retinal neurodegeneration in the early stage of diabetes. Methods Male Wistar rats weighing about 200 g were used to create diabetic animal model by injecting STZ. Wistar rats were killed by heart perfusion with 4% FDP at 1-week, 2-week and 1-month after diabetes. The dissected pretectal area was used to determine the expression of BDNF, NGF and GFAP with immunohistochemistry. Results In pretectal area of diabetic rat, the expression of BDNF and NGF began to decrease from 1-week DM, the expression of GFAP began to increase from 2-week DM. Conclusions There are neuron damage and neurotrophin decrease in the pretectal area in the early stage of diabetes. Neurodegeneration and neurotrophin decrease in pretectal area, which is the target tissue of retina, might be one of the reasons resulting in retinal neurodegeneration at the early stage of diabetes.
