The relationship between N5,10-methylenetetrahydrofolate reductase (MTHFR) gene polymorphism and diabetic cardiovascular disease
- VernacularTitle:亚甲基四氢叶酸还原酶677C→T及1298A→C基因多态性与糖尿病心血管病变的相关性
- Author:
Demin LIU
;
Xinping FAN
;
Demin YU
- Publication Type:Journal Article
- Keywords:
Polymorphism
- From:
Chinese Journal of Diabetes
2005;13(3):219-222
- CountryChina
- Language:Chinese
-
Abstract:
Objective To explore the relationship between MTHFR gene polymorphism and ~diabetic cardiovascular disease. Methods The MTHFR C677T and MTHFR A1298C gene polymorphisms were detectd by PCR-RFLP to compare MTHFR C677T and MTHFR A1298C genotype distribution and allele frequencies among three groups. Enrolled were 84 healthy individuals (NC) and 158 T2DM subjects who were classified into two groups, i.e. non-diabetes complications (NDC) and ~diabetic cardiovascular disease (DC). Results Patients with diabetic cardiovascular disease had higher frequencies of MTHFR C677T mutation genotype and T allele than control and non-diabetes complications subjects, and had lower folate levels (P<0.001). There were no significant differences in MTHFR A1298C genotype distribution and allele frequencies among three groups (P>0.05). A logistic regression analysis demonstrated that MTHFR C677T and age were the independent predictors of DC. Conclution There is a strong correlation between the polymorphism of MTHFR C677T and diabetic cardiovascular disease.
