Prilimanary investigation of commence time of liver specific phase on Sonazoid contrast-enhanced ultrasound

VernacularTitle:Sonazoid超声造影肝实质特异相开始时间的初步探讨
Author: Guangjian LIU ; Mingde Lü ; Moriyasu FUMINORI ; Xiaoyan XIE ; Qiao JI ; Ming XU ; Shuguang ZHENG ; Wei WANG ; Yongdong LIU
Publication Type:Journal Article
Keywords: Ultrasonography; Microbubbles; Liver
From: Chinese Journal of Ultrasonography 2012;21(10):888-892
CountryChina
Language:Chinese
Abstract: Objective To investigate commence time of liver specific phase on Sonazoid contrastenhanced ultrasound.Methods Rats were administrated with saline (n =6),SonoVue (n =24) and Sonazoid(n =24),respectively.Liver perfusion was performed at 2 min,5 min,10 min and 20 min in situ.Changes of liver enhancement caused by perfusion were quantitatively analyzed.Results Degree of liver enhancement without administration of contrast agent increased after perfusion.In SonoVue group,liver enhancement decreased after perfusion at 2 min and 5 min and increased at 10 min and 20 min significantly.In Sonazoid group,liver enhancement decreased dramatically at 2 min after perfusion,but no changes were found at 5 min,10 min and 20 min after perfusion.Conclusions Liver specific phase on Sonazoid CEUS can begin as early as 5min after administration of contrast agent.