Synergistic cytotoxic effects of tumor necrosis factor-related apoptosis-inducing ligand combined with valid drugs on panreatic carcinoma
10.3760/cma.j.issn.1673-4203.2011.12.019
- VernacularTitle:肿瘤坏死因子相关凋亡诱导配体与胰腺癌及相关药物研究
- Author:
Su MA
;
Jiahua ZHOU
- Publication Type:Journal Article
- Keywords:
Panceatic carcinoma;
Tumor necrosis factor-related apoptosis-inducing ligand
- From:
International Journal of Surgery
2011;38(12):847-850
- CountryChina
- Language:Chinese
-
Abstract:
Since the tumor necrosis factor-related apoptosis-inducing ligand was found as a suitable agent for anticancer therapies,study on tumor research has been attaching more importance to it.Utilized the progress on the study of TRAIL on pancreatic carcinoma aspect recent years and standed the principle in TRAIL inducing pancreatic carcinoma apoptosis,this article first simply reviewed the resistance theory of TRAIL on pancreatic carcinoma.Following the trail of identified resistance theory,carring the method of increasing TRAIL's sensibility with protein inhibition,signal regulation,ect,some new treatments have been received,which are described along with the antitumor effect of TRAIL combined with mature treatment in pancreatic carcinoma,and simply assessed at last in the article,to provide a reference on the synergistic cytotoxic effects of TRAIL combined with valid drugs on panreatic carcinoma.
