Progression of microRNA in esophageal cancer
10.3760/cma.j.issn.1673-422X.2011.12.014
- VernacularTitle:食管癌相关微小RNA研究进展
- Author:
Jiangliu YU
;
Zhiqiang LING
;
Weimin MAO
- Publication Type:Journal Article
- Keywords:
MicroRNAs;
Esophageal neoplasms
- From:
Journal of International Oncology
2011;38(12):920-922
- CountryChina
- Language:Chinese
-
Abstract:
Researches find that microRNAs(miRNAs) participate in cell proliferation,differentiation and apoptosis.Dysregulation of miRNA exist in almost all kinds of tumors,including esophageal cancer.MiRNAs bind to mRNA of oncogene or tumor suppressor gene by perfectly or partly base-pair complementarity,and then,promote mRNA degradation or inhibit translation of target mRNA.Recently studies have comfirmed that miRNA functions as a significant regulator in esophageal cancer and it is involved in tumorigenesis,development and prognosis.MiR-21 binds to programmed cell death 4(PDCD4) mRNA and inhibits the translation of PDCD4,then promotes tumorigenesis of esophageal cancer.MiR-106-25 polycistron is activated by genomic amplification,and then suppresses the expressions of P21 and Rim,and subsequently promotes the occurrence and progress of esophageal cancer.
