Expression and clinical significance of MIF in the ectopic endometrium and eutopic endometrium of ovarian endometriosis patients
10.3760/cma.j.issn.1008-6315.2011.12.014
- VernacularTitle:卵巢子宫内膜异位症患者异位和在位内膜中巨噬细胞移动抑制因子的表达及其临床意义
- Author:
Xiaohua XIE
;
Xiaohong YU
;
Huihong ZENG
;
Xiaoling ZHANG
- Publication Type:Journal Article
- Keywords:
Ovarian Endometriosis;
Macrophage migration inhibitory factor;
Immune;
Angiogenesis
- From:
Clinical Medicine of China
2011;27(12):1266-1268
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the significance of macrophage migration inhibitory factor(MIF) in ovarian endometriosis (OEms).Methods MIF of ectopic endometriumeutopic endometrium in OEms and endometrium in non-endometriosis (30 cases in every group ) was detected by Elivision TM plus immunohistochemical.Quantitative images analytical system was performed with computer to analyze the mean absorbance(A) of MIF.Results The A of MIF in ectopic and eutopic endometrium of OEms and the normal control was respectively ( 0.180 ± 0.013 ),( 0.158 ± 0.022 ) and ( 0.143 ± 0.029 ),there was statistical significance between groups ( F =47.676,P ＜ 0.001 ).The expression of MIF in proliferative phase of eutopic endometrium of OEms was(0.157 ±0.018),extremely stronger than that in the same phase of the normal control (0.146 ± 0.029 ) ( t =2.656,P =0.009 ) ; and MIF in secretory phase of eutopic endometrium of OEms was (0.160±0.028),obviously higher than that in the same phase of the normal control(0.137 ±0.030) (t =3.059,P =0.003).Conclusion The MIF may play a significant role in the pathogenesis and development of ovarian endometriosis.
