Clinical study on 48 cases of uremic maintenance hemodialysis patients with helicobacter pylori-negative chronic erosive gastritis
10.3760/cma.j.issr.1008-6315.2011.12.024
- VernacularTitle:尿毒症维持性血液透析并发幽门螺杆菌阴性慢性糜烂性胃炎48例疗效观察
- Author:
Hu ZHANG
;
Handong WANG
;
Shenghua DU
;
Chuntian ZHANG
;
Zhongrong ZHOU
- Publication Type:Journal Article
- Keywords:
Uremia;
Maintenance hemodialysis;
Helicobacter pylori;
Chronic erosive gastritis;
Pantoprazole;
Marzulene-S
- From:
Clinical Medicine of China
2011;27(12):1289-1291
- CountryChina
- Language:Chinese
-
Abstract:
Objective To explore effective treatment of uremic hemodialysis patients with chronic helicobacter pylori-negative erosive gastritis.Methods Fourty-eight cases of uremic hemodialysis patients with helicobacter pylori-negative chronic erosive gastritis were diagnosed by detection of helicobacter pylori and endoscopic examination.Fourty-eight patients were randomly divided into two groups,treatment group (24 patients) with oral pantoprazole 40 mg,once a day,combinding with oral Marzulene-S particles,each 0.67 g,three times a day,the control group (24 cases ) only with the dose of pantoprazole treatment.Effect of treatment was compared in these two groups after treatment for 21 days.Results Twenty-one days after treatment,the clinical symptoms of uremic hemodialysis patients with upper gastrointestinal improved in treatment group,and the performance of endoscopic and histopathological has varying degree of improvement.It shows that pantoprazole combined with Marzulene-S treatment group has a significant effect than that single treatment with pantoprazole group.In the treatment group,the total effective rate was 95.83％,however it was 83.33％ in the control group( U =2.716,P ＜ 0.01 ).Repair of mucosal lesions were significantly different between the two groups ( total effective rate 83.33％ vs 45.83％,U =2.349,P ＜ 0.05 ).Conclusion Pantoprazole combined with Marzulene-S therapy has a significant effect on uremic hemodialysis patients with chronic Helicobacter pylori-negative erosive gastritis.
