Clinical effect of simvastatin combined with valsartan in treatment of chronic heart failure and its affection on brain natriuretic peptide and heart function
10.3760/cma.j.issn.1673-4904.2011.33.007
- VernacularTitle:辛伐他汀联合缬沙坦治疗慢性心力衰竭患者的疗效及对脑钠尿肽和心功能的影响
- Author:
Jinhai WANG
- Publication Type:Journal Article
- Keywords:
Heart failure,congestive;
Natriuretic peptide,brain;
Simvastatin;
Valsartan
- From:
Chinese Journal of Postgraduates of Medicine
2011;34(33):18-20
- CountryChina
- Language:Chinese
-
Abstract:
ObjectiveTo observe the effect of simvastatin combined with valsartan in treatment of chronic heart failure(CHF) and its affection on brain natriuretic pepfde(BNP) and heart function.Methods Ninety-six cases of CHF patients were classified into two groups by random digits table,which control group of 48 cases were treated with normal therapy,and observation group of 48 cases were treated with simvastatin combined with valsartan at the base of normal therapy.The clinical effect,BNP and heart function between two groups were compared.ResultsThe clinical effective rate in observation group and control group was 85.4％ (41/48) and 70.8％ (34/48) (P ＞ 0.05).The levels of BNP,left ventricular end-systolic dimension (LVESD),left ventricular end-diatolic dimension(LVEDD) and left ventricular ejection fraction (LVEF)after treatment were (0.72 ± 0.14) μ g/L,(36.14 ± 3.92) mm,(46.85 ± 4.11 )mm and (44.62 ± 3.38)％ in observation group,while ( 1.21 ± 0.22 ) μ g/L,(41.32 ± 4.22 ) mm,(54.31 ± 4.96 ) mm and (41.28 ± 2.25 )％in control group.After treatment,the levels of BNP,LVESD and LVEDD were significantly decreased,LVEF was significantly higher in both groups (P＜ 0.05).Moreover,the levels of BNP,LVESD and LVEDD in observation group were significantly lower than those in control group (P＜ 0.05),LVEF was significantly higher than that in control group (P＜ 0.05 ).ConclusionSimvastatin combined with valsartan in treatment of CHF can enhance the clinical effect,decrease BNP level and improve heart function,which can be applied in clinic.
