Clinical manifestations and pathological characteristics of 1gA nephropathy with hyperuricemia
10.3760/cma.j.issn.1007-7480.2011.12.007
- VernacularTitle:伴高尿酸血症的IgA肾病临床与病理分析
- Author:
Aiping ZHANG
;
Lei ZHANG
;
Yaohai DING
;
Yanxia WANG
;
Yunshan GUO
;
Shumei SHI
;
Zhen LI
- Publication Type:Journal Article
- Keywords:
Uric acid;
Glomerulonephritis,IgA;
Clinical manifestations;
Pathological characteristics
- From:
Chinese Journal of Rheumatology
2011;15(12):825-828
- CountryChina
- Language:Chinese
-
Abstract:
Objective To explore the effect of serum uric acid on the clinical manifestations,pathological characteristics and prognosis of IgA nephropathy.Methods Four hundred and fifty-six cases of primary IgA nephropathy confirmed by renal biopsy from Jan 2007 to Oct 2010 in the Ji'nan Military General Hospital were reviewed retrospectively.The clinical manifestations and pathological characteristics of all the patients were analyzed,x2-test and t-test were used for statistical analysis.Results There were 127 cases with hyperuricemia in 456 IgAN patients (27.9％).The mean age,percentage of male patients,number of patients with hypertension,the serum cholesterol and triglyceride level,body mass index (BMI),serum creatinine and 24 hour urine protein level in hyperuricemia group were significantly higher than those with normal serum uric acid (P＜0.01).The renal pathological changes,glomerular score (8.1 ±0.8 v 5.3t0.9 ),tubulointerstitial score (4.2±0.4 vs 2.7±0.4) and vasculopathy score ( 1.43±0.60 vs 0.76±0.29) in the hyperuricemia group were more severe than those with normal serum uric acid (P＜0.01).Conclusion High level of serum uric acid can affect IgA nephropathy significantly.It is effe-ctive to delay the kindey damage and progression of IgA nephropathy by decreasing the level of uric acid and control the clinical parameters listed above.
