Association study between G-protein β3 subunit gene polymorphism and antipsychotic agent-induced obesity
10.3760/cma.j.issn.1674-6554.2011.12.015
- VernacularTitle:G蛋白β3亚单位基因多态性与抗精神病药源性肥胖的相关性
- Author:
Wenyue ZHANG
;
Xiaofei QI
;
Zhong YANG
;
Meifen WANG
;
Fenghua GU
;
Chunming XUAN
;
Xiaodong HAN
- Publication Type:Journal Article
- Keywords:
G-protein β3 subunit;
Genetics;
Polymorphism;
Antipsychotic agents;
Obesity
- From:
Chinese Journal of Behavioral Medicine and Brain Science
2011;20(12):1101-1103
- CountryChina
- Language:Chinese
-
Abstract:
Objective To explore the relationship between G-protein β3 subunit (GNB3) gene C825T polymorphism and antipsychotic agent-induced obesity.Methods 126 schizophrenic inpatients with long-term antipsychotics treatment were collected.According to body mass index ( BMI),patients were divided into obesity group ( n =62) and non-obesity group ( n =64).The GNB3 gene C825T polymorphism was detected by polymerase chain reaction and DNA sequencing technique.Levels of fasting blood glucose,2-hour postprandial blood glucose,blood lipids and blood uric acid of all patients were routinely measured.Results (1)The GNB3 gene C825T polymorphism were found in obesity group and non-obesity group respectively,and the distribution of genotypes in two groups were both consistent with Hardy-Weinberg equilibrium.(2)There was no significant difference in genotype frequencies between obesity group ( CC 17.75％,CT 58.06％,TT 24.19％ ) and non-obesity group( CC 18.75％,CT 62.50％,T T 18.75％ )( x2 =0.59,P ＞ 0.05 ).There was also no significant difference in allele frequencies between obesity group ( C 46.77％,T 53.23 ％ ) and non-obesity group ( C 50％,T 50％ ) ( x2 =0.26,P ＞ 0.05 ).(3)No significant differences were observed in BMI,fasting blood glucose,2-hour postprandial blood glucose,blood lipids and blood uric acid among different genotype groups (all P ＞ 0.05 ).Also no significant differences were observed in BMI,fasting blood glucose,2-hour postprandial blood glucose,blood lipids and blood uric acid between Tallele carrier (TT and CT genotypes) and T-allele non-carrier( CC genotype) ( all P ＞ 0.05 ).Conclusion The GNB3 gene C825T polymorphism may not be a genetic risk factor for antipsychotic agent-induced obesity.
