Butylphthalide improves cerebrovascular reactivity in patients with severe intracranial internal carotid artery stenosis
10.3760/cma.j.issn.1673-4165.2011.11.005
- VernacularTitle:丁苯酞改善重度颈内动脉颅内段狭窄患者的脑血管反应性
- Author:
Min LI
;
Wen SUN
;
Xuegan LIAN
;
Chaolai LIU
;
Xinfeng LIU
- Publication Type:Journal Article
- Keywords:
3-n-Butylphthalide;
Carotid stenosis;
Brain ischemia;
Cerebrovascular disorders;
Vasomotor system;
Ultrasonography,Doppler,transcranial
- From:
International Journal of Cerebrovascular Diseases
2011;19(11):824-828
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the effect of butylphthalide on cerebrovascular reactivity (CVR) in patients with severe intracranial internal carotid stenosis.Methods The patients with severe intracranial internal carotid stenosis diagnosed by cerebral angiography in Nanjing Stroke Registry Program from January 2010 to November 2010 were randomly divided into either the butylphthalide group or the control group.All patients received the oral drugs for ischemic cerebrovascular disease that met the guideline criteria,and butylphthalide 20 mg,3 times a day orally was added in the butylphthalide group.The CVR was evaluated by transcranial Doppler and CO2 inhalation challenge test,and reexamined 3 months after treatment.Results A total of 81 patients met the inclusion criteria,11 (13.6％) were lost to follow-up,and finally 70 (n =35 in each group) were included in the analysis.The mean age of the patients was 55.2 ± 9.0 years,47 of them were male and 23 were female.The degree of vascular stenosis was 72％ to 99％ (mean 79.4％ ± 9.5％).The CVR was improved significantly after 3 months of treatment in the butylphthalide group than that in the control group (P =0.007),but it was not improvedsignificantly in the control group (P =0.330).All the patients did not have ischemic stroke events during the medication.No serious adverse reactions occurred in the butylphthalide group.Conclusions Butylphthalide may improve the CVR in patients with severe intracranial internal carotid stenosis.
