MicroRNAs and stroke
10.3760/cma.j.issn.1673-4165.2011.11.012
- VernacularTitle:微小RNA与卒中
- Author:
Li WU
;
Yongjun JIANG
;
Gelin XU
;
Xinfeng LIU
- Publication Type:Journal Article
- Keywords:
MicroRNAs;
Brain ischemia;
Stroke;
Neuroprotective agents
- From:
International Journal of Cerebrovascular Diseases
2011;19(11):857-863
- CountryChina
- Language:Chinese
-
Abstract:
MicroRNAs (miRNAs) are endogenous non-coding RNAs composed of 18-25 nucleotides,and they may play a role in gene regulation through completely or partially binding to target gene mRNA complementary sequences and make it degrade or prevent its translation.miRNAs play important roles in the onset and pathophysiological processes of ischemic stroke.This article reviews the roles of miRNAs in the etiology of ischemic stroke and pathophysiological mechanisms after stroke,and the potential application of miRNAs is prospected.
