TESTIN tumor suppressor gene in endometrial cancer tissues

VernacularTitle:抑癌基因TESTIN在子宫内膜癌组织中的表达
Author: Ruofan DONG ; Hong PU ; Zhenyu ZHANG ; Yurong MAO ; Jinjin YU
Publication Type:Journal Article
Keywords: Genes,tumor suppressor; Endometrial neoplasms/ME
From: Journal of Chinese Physician 2011;13(11):1452-1454
CountryChina
Language:Chinese
Abstract: ObjectiveTo investigate the expression of TESTIN gene in endometrial carcinoma and explore the functions of this gene in tumor development and progression.MethodsqRT-PCR and immunochemical staining assay were used to determine the mRNA and protein level of TESTIN in the tumor tissues,and the relationship between TESTIN expression and clinical pathology characteristics was analyzed.Results Compared to normal tissue,76.5％ (52/68) tumor tissues showed TESTIN reduced ( P ＜ 0.01 ),furthermore,this reduction in the subgroup of endometrioid adenocarcinoma was significant,but it was rarely observed in the subgroup of serous papillary adenocarcinoma.ConclusionsTESTIN was obviously down regulated in endometrail carcinoma,especially in endometrioid adenocarcinoma,which indicated TESTIN played an important role in tumorigenesis of uterine.