Study in the correlativity between liver shear-wave velocities and liver fibrosis stages of patients with chronic hepatitis B
10.3760/cma.j.issn.1004-4477.2011.11.010
- VernacularTitle:慢性乙型肝炎患者肝剪切波速度与肝纤维化分期的相关性研究
- Author:
Xingtian WANG
;
Qiaoying ZHU
;
Rong WANG
;
Jianhua CUI
;
Peipu SHEN
;
Xuebing YAN
- Publication Type:Journal Article
- Keywords:
Ultrasonography;
Liver cirrhosis;
Hepatitis B,chronic;
Virtual touch tissue quantification
- From:
Chinese Journal of Ultrasonography
2011;20(11):953-956
- CountryChina
- Language:Chinese
-
Abstract:
Objective To explore the correlativity between liver shear-wave velocities and liver fibrosis stages in chronic hepatitis B patients.Methods One hundred and twelve patients with chronic hepatitis B accepted virtual touch tissue quantification (VTQ) testing to obtain shear-wave speed and compared to histological stages.Each patient received VTQ measurements in right lobe of liver.The standards of histological examination of the stages of fibrosis refered to the Hepatitis Pathology Diagnostic Standard Xi'an formulated in 2000.Results Of 112 patients,S0,S1,S2,S3 and S4 were 15,17,15,23 and 42 respectively.There was no significant statistically difference of the mean values of liver shear-wave speed between S0 and S1,while among the rest subgroup had significant statistically differences by multiple comparisons.The areas under the ROC curves were 0.94 for S2,0.87 for S3,and 0.95 for S4.The cut-off values of the shear wave velocity were as follows:1.27 m/s for S2(sensitivity 80.0％,specificity 89.5％),1.43 m/s for S3 (sensitivity 71.8 ％,specificity 87.7 ％ ) and 1.79 m/s for S4 (sensitivity 83.3 ％,specificity 89.4％).Hepatic fibrosis expressed by the histological scale correlated well with the VTQ values of all patients ( r =0.92).Conclusions Along with the increase of liver fibrosis degree,the hepatic parenchyma shear wave velocities increase gradually.The more advanced the degree of fibrosis,the higher the shear wave velocities.
