Disruption of liver blood perfusion by microbubbles enhanced ultrasound
10.3760/cma.j.issn.1004-4477.2011.11.023
- VernacularTitle:超声联合微泡阻断兔正常肝血流的再研究
- Author:
Shengzheng WU
;
Tao LI
;
Yang ZHAO
;
Lu LI
;
Qing LIU
;
Xiaochen ZHAO
;
Yu ZHONG
;
Zheng LIU
- Publication Type:Journal Article
- Keywords:
Ultrasonography;
Microbubbles;
Liver;
Cavitation
- From:
Chinese Journal of Ultrasonography
2011;20(11):988-991
- CountryChina
- Language:Chinese
-
Abstract:
Objective To explore the feasibility of extending liver blood perfusion cessation by ultrasound combining microbubbles.Methods The livers of 9 healthy rabbits were treated with a pulsed therapeutic ultrasound device,in presence of microbubbles.For quantification of liver perfusion,contrastenhanced ultrasonography was performed on 6 rabbits before treatment and at different time points of 0 min,30 min,60 min and 48 hours after treatment.Pathological examination of the treated livers was performed immediately after treatment on the other 3 rabbits.Results The liver blood perfusion almost vanished immediately after treatment,remained at a low perfusion level from 30 to 60 min,and completely recovered 48 hours later.The peak intensity dropped from ( - 51.88 ± 4.26)dB to ( - 62.53 ± 4.83)dB after treatment and rose up to ( - 52.00 ± 4.60) dB 48 hours later.The peak intensities before treatment and 48 hours after treatment were significantly higher than those of 0 min,30 min and 60 min time points after treatment( P ＜0.05).Pathological examination showed significant swelling of hepatocytes and hemorrhage around portal veins.Conclusions Microbubbles enhanced ultrasound can induce liver blood perfusion cessation for up to 1 hours.The mechanism could be swelling of hepatocytes and hemorrhage of portal track.
