Risk factors for reduced kidney function in patients with acute ischenic stroke A hospital-based retrospective case series study
10.3760/cma.j.issn.1673-4165.2011.11.004
- VernacularTitle:急性缺血性卒中患者肾功能下降的危险因素——基于医院的回顾性病例系列研究
- Author:
Lei SHENG
;
Lankun ZHANG
;
Dan HU
;
Lan PENG
;
Dinghua LIU
;
Zufu ZHU
;
Caixia DING
;
Jing XIAO
;
Chuanyou LI
;
Yujia ZHU
;
Zhixiang LING
;
Han JIANG
;
Yinyan TANG
- Publication Type:Journal Article
- Keywords:
Stroke;
Brain ischemia;
Renal insufficiency,chronic;
Glomerular filtration rate;
Risk factors
- From:International Journal of Cerebrovascular Diseases
2011;19(11):818-823
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the risk factors for reduced renal function in patients with ischemic stroke.Methods The medical records of patients with ischemic stroke were analyzed retrospectively.They were divided into normal renal function group and reduced renalfunction group.Reduced renal function was defined as estimated glomerular filtration rate (eGFR) ＜60 ml/(min·1.73 m2).Multivariate logistic regression analysis was used to identify the risk factors for reduced renal function in patients with ischemic stroke.Results A total of 805 patients with ischemic stroke were enrolled in the study.8.8％ of patients had a reduced renal function.There was no significant differences in the proportion of patients with mild and moderate neurological deficit between the reduced renal function group and the normal renal function group (all P ＞ 0.05),however,the proportion of patients with severe neurological deficit was significantly higher than that in the normal renal function group (8.4％vs.2.6％,x2 =5.573,P =0.017).The proportion of small artery occlusion in the reduced renal function group was sigaificantly higher than that in the normal renal function group (66.2％ vs.46.5％,x2 =9.962,P =0.002),and the proportion of large artery atherosclerosis was significantly lower than that in the normal renal function group (19.7％ vs.43.5％,x2 =15.045,P =0.000).Multivariate logistic regression analysis indicated that old age (odds ratio [ OR] 3.301,95％ confidence interval [ CI],1.575 to 6.918; P=0.002) was the most important independent risk factor for reduced renal function,then was female (OR,2.291,95％ CI 1.355to 3.872; P=0.002) and hyperlipidemia (OR,2.527,95％ CI 1.095 to 5.831; P=0.030).Conclusions Reduced renal function in patients with ischemic stroke is strongly associated with old age,female,and hyperlipidemia.
