p38 MAPK signaling transduction pathway and cerebral ischemia
10.3760/cma.j.issn.1673-4165.2011.11.011
- VernacularTitle:p38MAPK信号转导通路与脑缺血
- Author:
Pingping ZHU
;
En XU
- Publication Type:Journal Article
- Keywords:
p38 mitogen-activated protein kinases;
Signal transduction;
Brain ischemia;
inflammation;
apoptosis;
preconditioning
- From:
International Journal of Cerebrovascular Diseases
2011;19(11):853-856
- CountryChina
- Language:Chinese
-
Abstract:
p38 mitogen-activated protein kinase (MAPK) is an important intracellular signaling transduction pathway.Its major role is involved in inflammatory regulation and apoptosis.p38 MAPK is activated during the cerebral ischemia.Its expression level and the upstream and downstream protein phosphorylation levels will change.Ischemic preconditioning may mediate the survival or death of neuronal cells after cerebral ischemia through signaling transduction pathway.
