Analysis of cardiotoxicity of chemotherapy in 30 cases with gynecological cancer

VernacularTitle:妇科恶性肿瘤化疗期间发生心脏毒性反应30例临床分析
Author: Bingjie LIU ; Xiaoping LI ; Jianliu WANG ; Yan WU ; Lihui WEI
Publication Type:Journal Article
Keywords: Genital neoplasms,female; Drug therapy; Heart disease; Toxic Actions
From: Chinese Journal of Obstetrics and Gynecology 2011;46(12):884-887
CountryChina
Language:Chinese
Abstract: Objective To investigate the occurrence of cardiotoxicity of chemotherapeutic drugs in gynecological cancer patients without heart disease,and patients with coronary heart disease or congenital heart disease for providing a basis for the clinical prevention of heart side effects during chemotherapy.Methods Thirty cases with gynecological cancer complication with or without coronary heart disease or congenital heart disease before or during chemotherapy admitted from Jan.2004 to Dec.2010 were retrospectively analyzed.Results For all 30 patients,there were heart failures in 3 cases ( 10％,3/30),myocardial infarction in 3 cases (10％,3/30),angina pectoris in 1 cases (3％,1/30),ST-T or T-wave changes in 9 cases (30％,9/30),and arrhythmia in 8 cases (27％,8/30).Conclusions Cancer chemotherapy drugs to the heart may produce an immediate or long-term toxicity,in which could significantly effects on the survival and prognosis of patients.It is very important to prevent the occurrence of cardiotoxicity of chemotherapeutic drugs in gynecological cancer patients with heart diseases during chemotherapy.