KAI1, MMP9 in endometriosis sickness expression and significance

VernacularTitle:KAI1、MMP-9在子宫内膜异位症中的表达及意义
Author: Xuemei ZHANG ; Fengying MA ; Lei LIANG ; Ding DING ; Lishu WU ; Meisong LU
Publication Type:Journal Article
Keywords: Proto-oncogene proteins/ME; Matrix metalloproteinase 9; Genes,tumor suppressor; Endometriosis/ME
From: Journal of Chinese Physician 2011;13(11):1473-1475
CountryChina
Language:Chinese
Abstract: ObjectiveTo discuss the expression of tumor shift suppressor gene KAI1,matrix metal proteinase 9 (MMP-9) in endometriosis sickness in dystopia internal membrane and its significance.MethodsIn 53 patients and 30 healthy controls,the expression of KAI1,MMP-9 in the endometriosis was detected with immunohistochemistry SP method,and the relationship was analyzed.ResultsKAI1 had low expression in EMS patients,while MMP-9 was highly expressed.In the control group,KAI1 was highly expressed while MMP-9 lowly expressed,and the differences between two groups were remarkably significant (P ＜0.05).KAI1 and the MMP-9 expression showed negative correlation between two groups.Conclusions KAI1 and MMP-9 was negatively expressed in EMS,which may play a role in the EMS prognosis.KAI1 and MMP-9 may be served as the prognosis and monitor markers for EMS.