Macrophage migration inhibitory factor and hypothalamo-pituitary-adrenal function during sepsis inchildren
10.3760/cma.j.issn.1673-4408.2011.06.014
- VernacularTitle:巨噬细胞移动抑制因子与脓毒症患儿肾上腺皮质功能关系的研究进展
- Author:
Liuhong SHI
;
Ying WANG
;
Juan QIAN
- Publication Type:Journal Article
- Keywords:
Spesis;
Adrenal insufficiency;
Macrophage migration inhibitory factor
- From:
International Journal of Pediatrics
2011;38(6):572-575
- CountryChina
- Language:Chinese
-
Abstract:
The hypothalamo-pituitary-adrenal (HPA) axis modulates the inflammatory response during sepsis.Macrophage migration inhibitory factor (MIF) is a unique cytokine and critical mediator of host defenses in sepsis and septic shock.MIF counteracts the anti-inflammatory activity of glucocorticoid (GC).The interaction of GC and MIF might cause adrenal insufficiency.MIF could be a valuable clinical marker of adrenal insufficiency in sepsis.
