Influence of artificial liver support system on bone marrow stem cell differentiation factors in patients with chronic severe hepatitis B
10.3760/cma.j.issn.1000-6680.2011.11.011
- VernacularTitle:人工肝支持系统对慢性乙型重型肝炎患者骨髓干细胞分化因子水平的影响
- Author:
Yang FAN
;
Qin BO
;
Qin FENG
- Publication Type:Journal Article
- Keywords:
Liver,artificial;
Hepatitis B,chronic;
Stem cells;
Bone marrow cells;
Cell differentiation;
Hepatocyte growth factor;
Fibroblast growth factor-4;
Epidermal growth factor;
Basic fibroblast growth factor
- From:
Chinese Journal of Infectious Diseases
2011;29(11):674-678
- CountryChina
- Language:Chinese
-
Abstract:
Objective To study the influence of artifical liver support system (ALSS) on bone marrow stem cell (BMSC) differentiation factors in patients with chronic severe hepatitis B.Methods Fifty patients with chronic severe hepatitis B were divided into ALSS treatment group (n=25) and control group (n=25).The patients in control group received combined medical treatment and those in ALSS treatment group received ALSS treatment within 1 week of admission on the basis of combined medical treatment.The concentrations of hepatocyte growth factor(HGF),fibroblast growth factor-4 (FGF-4),epidermal growth factor (EGF) and basic fibroblast growth factor (bFGF) were detected before and 2 weeks after therapy.The data were analyzed by t test.Results The serum levels of HGF,FGF-4,EGF and bFGF of patients before ALSS treatment in treatment group were (689.10± 337.68) ng/L,(124.88±87.67) ng/L,(323.85±44.40) ng/L and (9.29± 1.38) ng/L,respectively; while the levels of those cytokines after ALSS treatment were (1081.50±356.66) ng/L,(110.76±79.71) ng/L,(347.80±71.73) ng/L and (9.57±1.15) ng/L,respectively,among which HGF level increased significantly after ALSS treatment (t =10.042,P＜0.01) and was higher than control group(t=6.670,P＜0.01).However,the levels of HGF,FGF-4,EGF and bFGF were not significantly different from those in the control group.And levels of all HGF,FGF-4,EGF and bFGF in control group were not statistically different before and after treatment.ConclusionALSS treatment can increase the serum HGF level but not FGF-4,EGF and bFGF,which may contribute to BMSC transdifferentiation that is involved in the hepatocyte repair and regeneration in chronic severe hepatitis B.
