The clinical features of 15 cases with severe enterovirus 71 ( EV71 ) infection and the genotype of EV71
10.3760/cma.j.issn.1673-4912.2011.06.012
- VernacularTitle:15例肠道病毒71型感染重症手足口病临床特征及病原基因型分析
- Author:
Ping JIN
;
Yuan LI
;
Jinhui XIAO
;
Chunyi LIU
;
Kan ZHANG
;
Likuan XIONG
;
Guangxing MAI
;
Guangqing YU
- Publication Type:Journal Article
- Keywords:
Hand,foot and mouth disease;
Critical illness;
Enterovirus 71;
Genotype
- From:
Chinese Pediatric Emergency Medicine
2011;18(6):518-520
- CountryChina
- Language:Chinese
-
Abstract:
Objective To explore the clinical feature of severe enterovirus 71 (EV71) associated hand foot and mouth disease (HFMD),and genotype of EV71.Methods Fluorescent quantitation PCR was done for detecting EV71.RT-PCR was performed to amplify VP1 for sequencing and identifying genotype.A retrospective analysis was performed based on the clinical data of 15 cases with severe EV71 infection.Results EV71 nucleotide was positive in all 15 cases.The genotype of EV71 was C4.All cases had abnormal temperature and followed with nervous symptoms in the early stage.Average time was 1.26 days from onset to severe complications appearance.Eleven cases progressed to neurogenic pulmonary edema.Four cases accepted nasal continuous positive airway pressure.Eleven cases accepted oral trachea cannula mechanical ventilation.Except for 3 cases died,one case abandoned,others 11 cases were cured.Conclusion The isolated strains of EV71 in this study are all C4 genotype.All cases with severe EV71 infection were followed with nervous symptoms in the early stage,most of whom would progress to neurogenic pulmonary edema.The mortality would be cut down by using mechanical ventilation in early stage.
