Standardized treatment of gastrointestinal stromal tumors
10.3760/cma.j.issn.1673-9752.2011.06.002
- VernacularTitle:胃肠道间质瘤的规范化治疗
- Author:
Cao HUI
;
Wang MING
- Publication Type:Journal Article
- Keywords:
Gastrointestinal stromal tumors;
Diagnosis;
Management
- From:
Chinese Journal of Digestive Surgery
2011;10(6):405-408
- CountryChina
- Language:Chinese
-
Abstract:
Gastrointestinal stromal tumors (GISTs) is a subset of mesenchymal tumors and represents the most common mesenchymal neoplasm of gastrointestinal tract.In the last decade,GISTs has become well known because of the effectiveness of imatinib mesylate.The molecular targets for tyrosine kinase receptor inhibitor are not only of importance for the treatment of patients but also useful for the development of a novel drug modalities and new strategies in basic cancer therapy.The improved understanding of the molecular mechanism of GISTs has made its diagnosis standardized.Many multicenter phase Ⅱor phase Ⅲ clinical trials have been completed to establish the role of adjuvant and neoadjuvant therapy.It is important to select the correct management strategy,which is multidisciplinary,integrated,and individualized.This paper provides an overview of the rational treatment of GISTs at present.
