Diagnosis and treatment progress of children's acute myeloid leukemia
10.3760/cma.j.issn.1673-4408.2011.06.012
- VernacularTitle:儿童急性髓系白血病诊治研究进展
- Author:
Sixi LIU
;
Feiqiu WEN
;
Changgang LI
- Publication Type:Journal Article
- Keywords:
Children;
Acute myeloid leukemia;
Diagnosis;
Treatment
- From:
International Journal of Pediatrics
2011;38(6):565-568
- CountryChina
- Language:Chinese
-
Abstract:
Acute mveloid leukemia(AML) is a heterogeneous group of leukemias that arise from clonal transformation of hematopoietic precursors.This review summarizes classification of pediatric AML,more precise risk-group stratification,ongoing phase Ⅲ studies and minimal residual diseasse monitoring.In addition,we discuss the opportunities for innovative chemotherapy drugs in refractory AML and relapsed AML,such as gemtuzumab ozogamicin,liposomal daunorubicin,clofarabine,cladribine and lmatinib.Finally,the roles of allogeneic hematopoietic stem cell transplantation in pediatric AML are also discussed.
