Progress of neonatal diabetes mellitus
10.3760/cma.j.issn.1673-4408.2011.06.024
- VernacularTitle:新生儿糖尿病研究进展
- Author:
Ying LIU
;
Yuhong TAO
- Publication Type:Journal Article
- Keywords:
Neonatal diabetes mellitus;
Gene mutation;
Therapy
- From:
International Journal of Pediatrics
2011;38(6):606-608
- CountryChina
- Language:Chinese
-
Abstract:
Neonatal diabetes mellitus ( NDM ),which was often misdiagnosed as type 1 diabetes in the past,is a heterogenous single-gene genetic disease.Permanent neonatal diabetes( PNDM )is mainly associated with mutation in KCNJ11,ABCC8,and insulin associated gene instead of immunity.The most common manifestation includes diabetic ketoacidosis,intrauterine growth retardation and dehydration.Gene examination contributes to the classification of NDM and corresponding targeted therapy.Oral sulfonylurea may be used in treating patients with gene mutation of ATP-sensitive K+ channel.
