Effect of intravenous immunoglobulin on immunity and outcome for sepsis in children
10.3760/cma.j.issn.1673-4912.2011.06.006
- VernacularTitle:静脉用免疫球蛋白对脓毒症患儿免疫状态及转归的影响
- Author:
Yi XIN
;
Daihong WAN
;
Qing CHU
;
Qi ZHAO
;
Xingjuan GAO
;
Aimin LI
- Publication Type:Journal Article
- Keywords:
Sepsis;
Intravenous immunoglobulin;
Immunity;
Children
- From:
Chinese Pediatric Emergency Medicine
2011;18(6):497-499
- CountryChina
- Language:Chinese
-
Abstract:
Objective To explore the effect of intravenous immunoglobulin (IVIG) on immunity and outcome for sepsis in children.Methods Eighty-four children who met the diagnosis of sepsis were included in study and divided into treatment group (36 cases) and control group (48 cases ).The patients in teatment group were administered IVIG with the dose of 1 g/kg.Peripheral venous blood samples of patients in both groups were collected before (0 h),24 h,72 h and 5 d after administration to detect the numbers of immunocyte including CD3 +,CD4 +,CD56 +,CD19 +,CD8 +cells by flow cytometry and the levels of cytokines including tumor necrosis factor (TNF)-at,interleukin (IL)-10,IL-1 7 by enzyme linked immunosorbent assay.The numbers of immunocyte and levels of cytokines and TNF-a/IL-10 were compared and the mortality at 28 days was assessed between two groups.Results The numbers of CD3 +,CD4 +,CD56 +,CD19 +cells and the levels of TNF-a,IL-17 and TNF-α/IL-10 of patients in teatment group were significantly decreased than those in control group at 24 h,72 h and 5 d afte administration ( P ＜0.05 ) and showed downtrend.However,the level of IL-10 increased significantly (P ＜ 0.05 ) and showed uptrend in treatment group.The number of CD8+ cells had no change.No difference of mortality was observed between two groups (27.7％,10/36 vs 16.6％,8/48,x2 =1.50,P =0.169,OR =1.92,95％ CI:0.671 ～5.510).Conclusion IVIG can suppress the immunity of children with sepsis and has no survival benefit.
