Changes of plasma corticotrophin releasing factor levels in the young rats with hypoxic-ischemic brain damage
10.3760/cma.j.issn.1673-4912.2011.06.019
- VernacularTitle:缺氧缺血性脑损伤幼年大鼠血浆中促肾上腺皮质激素释放因子水平变化
- Author:
Jing DONG
;
Yimin ZHU
;
Wenwu ZHOU
;
Fa YUAN
;
Chunyan DONG
;
Yonghao GUI
;
Chao CHEN
- Publication Type:Journal Article
- Keywords:
Hypoxic-ischemic brain damage;
Corticotrophin releasing factor;
Rat
- From:
Chinese Pediatric Emergency Medicine
2011;18(6):539-541
- CountryChina
- Language:Chinese
-
Abstract:
Objective To explore the changes of plasma corticotrophin releasing factor (CRF) levels in the young rats with hypoxic-ischemic brain damage.Methods Two hundred and forty young rats were randomly divided into three groups:hypoxic-ischemic brain damage group ( model group,n =80),sham-operated group ( n =80),and normal control group ( n =80).The plasma CRF levels of rats in three groups were detected at 1 h,3 h,6 h,12 h,l d,3 d,5 d and 18 d after hypoxia-ischemia,per ten rats for each time point.Plasma CRF levels were measured by radioimmunoassay.Results Plasma CRF levels of model group,shamoperated group and normal control group showed no significant difference in the young rats after 1 h,3 h,6 h,12 h of hypoxia-ischemia ( P ＞ 0.05 ).But plasma CRF levels in the model group were respectively significantly lower than those of sham-operated group and normal control group after 1 d and 3 d of hypoxia-ischemia ( P ＜0.001 ),and then recovered to the control group levels after 5 d and 18 d of hypoxia-ischemia ( P ＞0.05 ).Conclusion Hypoxia-ischemia affects plasma CRF levels in the young rats,which is related with the duration after hypoxia-ischemia.
