Environmental endocrine disruptors and abnormalities of sexual differentiation and sexual development inchildren
10.3760/cma.j.issn.1673-4408.2011.06.011
- VernacularTitle:环境内分泌干扰物与儿童性分化、性发育异常
- Author:
Xiangting LI
- Publication Type:Journal Article
- Keywords:
Endocrine disruptors;
Sexual differentiation;
Sexual development
- From:
International Journal of Pediatrics
2011;38(6):560-564
- CountryChina
- Language:Chinese
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Abstract:
Environmental endocrine disruptors are pollutants of many exogenous chemical classes,which are ubiquitous and persistent in the environment and can interfere with the body 's natural steroidogenesis,secretion,transport,and receptor binding,biotransformation and removal of other aspects,thus,they may disturb normal hormone maintaining the organism 's balance and regulating development process.Therefore,exposure to these pollutants is one of the biggest factors that induce sex differentiation and sexual abnormality in children,which has been proved by many data from epidemiological researches.Environmental endocrine disruptors may influence the sexual differentiation and sexual development process of children by disturbing the hypothalamus-pituitary-gonadal axis and affecting the biosynthesis,transport,receptor binding,metabolism and clearance of androgen as well as interacting with genes.
