Differentiation of mesenchymal stem cell into epithelium and application

VernacularTitle:间充质干细胞向上皮细胞的诱导分化及应用研究进展
Author: Chuanbao ZANG ; Dong LI
Publication Type:Journal Article
Keywords: Mesenchymal stem cell; Epithelial cell; Lung injury; Kidney; Cornea
From: International Journal of Pediatrics 2011;38(6):616-619
CountryChina
Language:Chinese
Abstract: Mesenchymal stem cells (MSC) is able to differentiate into a variety of epithelial cells,such as alveolar epithelium,tubular epithelium and corneal epithelial cells in vivo and in vitro under the given condition.After transfusion,MSC can effectively repair the injured lung epithelial cells,and relieve inflammation.MSC can also repair the renal tubular cell damage by reducing renal interstitial infiltration of inflammatory cells,promoting regeneration of renal tubular epithelial cells and inhibiting of apoptosis; Biological cornea can be available constructed by using MSC,which can availably repair the injured ocular surface.In the other hands,MSC can express keratinocyte growth factors and other cytokines,promoting limbal stem cell proliferation.In addition,MSC can also differentiate into pancreatic ductal epithelial cells,endometrial epithelial cells,spermatogenic epithelium and human retinal pigment epithelium.MSC has great application potential in epithelial diseases,and provide a good and effective choice in treatment of some epithelial diseases.