Effect of atorvastatin therapy before percutaneous coronary intervention on periprocedural myocardial injury

VernacularTitle:阿托伐他汀对经皮冠状动脉介入术患者心肌损伤的保护作用
Author: Fengzhen JIAO ; Yan ZHAO ; Xiaofang LIU ; Chunying YU
Publication Type:Journal Article
Keywords: Angioplasty,transluminal,percutaneous coronary; Myocardial stunning; Atorvastatin
From: Chinese Journal of Primary Medicine and Pharmacy 2011;18(24):3348-3349
CountryChina
Language:Chinese
Abstract: ObjectiveTo explore the effect of statin in reduction of my ocardial injury in patients undergoing percutaneous coronary intervention(PCI).MethodsTotal of 185 patients undergoing PCI were included,140 patients were received atorvastatin before PCI,while 145 were not given statins at the time of PCI.Creatine kinase-MB and troponin Ⅰ were measured at baseline and at 8 and 24 hours after the procedure.ResultsPost procedurul peak levels of troponin Ⅰ and creatine kinase-MB were(0.12 ±0.26) μg/L and(2.61 ± 3.07) μg/L in the observation group,which were significantly lower than(0.51 ± 1.14) μg/L and( 6.85 ± 14.38 ) μg/L in the control group( t =3.951,3.414,P ＜ 0.05).ConclusionPretreatment with atorvastatin for 7 days could significantly reduces procedural myocardial injury in elective PCI.