Effect of hydroxyethyl starch on tissue perfusion and serum TNF-α、IL-6、IL-8 levels in patients with severe acute pancreatitis
10.3760/cma.j.issn.1008-6706.2011.23.016
- VernacularTitle:羟乙基淀粉对急性胰腺炎患者组织灌注及血清肿瘤坏死因子、白细胞介素-6、-8水平的影响
- Author:
Jinting GAO
;
Ke QI
;
Dingding MIAO
;
Xinsheng CHENG
;
Fuyu WANG
;
Yongbin ZHENG
- Publication Type:Journal Article
- Keywords:
Pancreatitis;
Hydroxyethyl starch;
Tumor necrosis factor-alpha;
Interleukin-6;
Interleukin-8
- From:
Chinese Journal of Primary Medicine and Pharmacy
2011;18(23):3198-3200
- CountryChina
- Language:Chinese
-
Abstract:
Objective To observe effects of hydroxyethyl starch(130/0.4,voluven)on tissue perfusion and serum TNF-α,IL-6,IL-8 levels in patients with severe acute pancreatitis(SAP).Methods 60 SAP patients with non-operative treatment were randomly divided into voluven group and Ringer's solution group(n =30 per group).In addition to conventional drugs and treatment,of which voluven group daily 15ml/kg intravenously for 5 d;Ringer's solution group daily 20ml/kg intravenously for 5d.Hemodynamic parameters and tissue perfusion indicators were monitored,TN F-α,IL-6,IL-8 levels were examined after treatment 0,12,24,48,96 hours.Results Compared with Ringer solution group,Voluven group therapy high efficiency,faster raise MAP,ScvO2,Phi value,lower HR,Hct(t =2.785,3.126,4.132,3.168,2.218,all P ＜ 0.05).TNFα,IL-6 after 48h treatment,IL-8 after 96h treatment,both groups were significantly decreased,but the voluven group was significantly lower than Ringer's solution group(P ＜ 0.05).Conclusion Voluven could effectively and quickly maintain hemodynamic stability,improve the hemorheological and tissue perfusion,could be more conducive to improving the pancreatic microcirculation,thus inhibiting inflammatory cytokines TNF-α,IL-6,IL-8 release,and had favorable treatment effect on patients with SAP.
