Clinical observation on the effect of omeprazole combined with octreotide in treatment of patients with nonvariceal upper gastrointestinal hemorrhage
10.3760/cma.j.issn.1008-6706.2011.24.018
- VernacularTitle:奥美拉唑联合奥曲肽治疗非静脉曲张性上消化道出血
- Author:
Wang FANG
;
Liu LI
;
Hong ZHE
;
Yu JIAN
- Publication Type:Journal Article
- Keywords:
Varicose veins;
Upper gastrointestinal hemorrhage;
Omeprazole;
Octreotide
- From:
Chinese Journal of Primary Medicine and Pharmacy
2011;18(24):3350-3351
- CountryChina
- Language:Chinese
-
Abstract:
ObjectiveTo explore the clinical effect of omeprazole combined with octreotide in treatment of patients with non-variceal upper gastrointestinal hemorrhage.Methods96 patients with non-variceal upper gastrointestinal hemorrhage were randomly divided into two groups.All the cases were received basic treatment of fluid infusion,transfusion and nutritional support.The control group( n =48) was treated with omeprazole alone,and the treatment group(n =48) was treated with omeprazole and octreotide.The course of treatment was 3 days.The vital signs,24h urine output,the number of cases of rebleeding in 72 h and adverse drug reactions was observed and recorded.ResultsThe total effective rate in treatment group and control group was 91.7％ and 72.9％,respectively.The difference between the two groups was statistically significant( x2 =5.79,P ＜0.05 ).The time of hemostasis and blood transfusion volume in treatment group were significantly less than those in control group(t =7.69,9.91,all P ＜0.05).The rebleeding rates after 72 hours of hemostasis between the two groups(8.3％ vs 25.0％ ) was significantly different ( x2 =4.80,P ＜ 0.05 ).In the course of treatment,the side effects weren' t found in both groups.ConclusionOmeprazole combined with octreotide was more effective and safe than omeprazole alone in fast stopping bleeding and reducing rebleeding rate.
