Association of human leukocyte antigen-DRB1 gene with rheumatoid arthritis in North-China Han people
- VernacularTitle:利用新型分类体系评价人类白细胞抗原-DRB1基因与中国北方汉族人群类风湿关节炎的易感性
- Author:
Xu LIU
;
Jianping GUO
;
Yuan JIA
;
Xiaolan LU
;
Yi ZHAO
;
Xia LIU
;
Shiyao WANG
;
Chun LI
;
Xingyu WU
;
Feng CHENG
;
Xiaoxia LI
;
Yi ZHENG
;
Xuhua SHI
;
Haiyun LI
;
Cibo HUANG
;
Yongjing CHENG
;
Bei LAI
;
Yanhong HUANG
;
Tian WANG
;
Zhanguo LI
- Publication Type:Journal Article
- Keywords: Arthritis,rheumatoid; HLA-DRantigens; Epitopes; Disease susceptibility
- From: Chinese Journal of Rheumatology 2011;15(11):731-735
- CountryChina
- Language:Chinese
- Abstract: ObjectiveThis study is aimed to investigate the association of human leukocyte antigen (HLA)-DRB1 with rheumatoid arthritis (RA) in Chinese Han population.MethodsA total of 281 Chinese Han patients with RA and 202 healthy controls were recruited.DNA was extracted from PBMC and HLA typing was performed by sequence based typing and PCR-Sequence Specific Primer.The frequency of HLADRB1 was compared between patients and controls using x2 test with continuity correction.ResultsThe susceptible HLA-DRB1 alleles were * 0101,* 0102,*0404,* 0405,and * 0410 which belonged to QRRAA.DRRAA and DERAA were protective alleles.At genotypic level,The association of S3P and S3D was detected.However,the protective effect of S3D was shown to be in a recessive mode.ConclusionOur results have shown that there are racial differences in RA susceptibility between Chinese Han population and Caucasians.