Intervention effects of atorvastatin calcium tablets on soluble CD40 ligand and C-reactive protein in patients with cardiac angina
10.3760/cma.j.issn.0254-9026.2011.11.013
- VernacularTitle:阿托伐他汀钙片对心绞痛患者血清可溶性CD40配体与C反应蛋白的干预研究
- Author:
Qingling WANG
;
Yongquan YANG
- Publication Type:Journal Article
- Keywords:
CD40 ligand;
Coronary disease;
Angina pectoris;
C-reactive protein
- From:
Chinese Journal of Geriatrics
2011;30(11):938-940
- CountryChina
- Language:Chinese
-
Abstract:
ObjectiveTo investigate the intervention of level of atorvastatin calcium tablets (lipitor) on soluble CD40 (CD40L) and high sensitivity C-reactive protein (hs-CRP) in patients with angina.Methods 65 patients with coronary heart disease were divided into stable angina (SA group,n= 30) and unstable angina (UA group,n= 35).The vein blood was collected in the hospitalized morning,2,4,6 weeks after treatment and serum levels of hs-CRP and CD40L were measured and compared between the two groups.ResultsThe levels of soluable CD40L [(20.52± 2.91)μg/L] and CRP [(7.96±1.69) mg/L] in UA group were higher than SA group [(7.96±-1.35) tg/L and ( 1.58 ± 0.91 ) mg/L] (t = 21.705、18.493,both P＜ 0.05) before treatment,and after treatment,their levels in the two groups were significantly lower than pre-treatment (P＜0.01).ConclusionsCD40L and hs-CRP may involved in the pathophysiology of unstable angina process and can be used as an indicator reflecting vulnerable plaque.Lipitor might enhance stability of atherosclerotic plaque and prevent acute coronary events by reducing levels of CD40L and hs-CRP.
