Study on the effect and safety of sorafenib in treatment of patients with metastatic renal cell carcinoma
10.3760/cma.j.issn.1008-6706.2011.24.016
- VernacularTitle:索拉非尼治疗转移性肾细胞癌的疗效及安全性研究
- Author:
Hongxing HUANG
;
Zhijian LI
;
Yuqiong OU
;
Shijun SUN
- Publication Type:Journal Article
- Keywords:
Renal cell carcinoma;
Metastatic;
Sorafenib;
Targeted therapy
- From:
Chinese Journal of Primary Medicine and Pharmacy
2011;18(24):3346-3347
- CountryChina
- Language:Chinese
-
Abstract:
ObjectiveTo evaluate the effect and safety d sorafenib in treatment of patients with metastatic renal cell carcinoma.Methods40 patients with metastatic renal cell carcinoma,were given sorafenib tablets methanesulfonate treatment,the initial dose of 800mg/d,bid,continuous administration of 21d,stopping 7d,The adverse reactions,efficacy and immunohistochemistry results were observed.Results40 cases with metastatic renal cell carcinoma were not found complete remission (CR) and partial remission (PR) ; The 32 cases in stable disease (SD)(80.0％ ) and 8 cases ( 20.0％ ) in PD; The incidence of 28 cases ( 70.0％ ) in digestive system; The expression of positive rate 30.5％ of local in connexin 32,Cx32 was significantly lower than that 1.2％ in metastatic renal cell carcinoma( x2 =8.123,P ＜0.01 ),The expression of Cx32 was negatively correlated with the clinical stage( r =-0.419,P ＜0.05 ) ;The expression positive rate of vascular endothelial growth factor(VEGF) in renal cell carcinoma was significantly higher than 18.5％ in normal renal tissue( x2 =8.723,P ＜ 0.01 ) ; The expression positive rate 72.0％ in the limitations of renal cell carcinoma and metastatic renal cell carcinoma 89.1％ was not statistically significant( x2 =1.978,P ＞ 0.05 ).ConclusionSorafenibin for advanced kidney cancer had better disease control effect,and was new choice for treatment of metastatic renal cell carcinoma.
