Influence of L-carnitine on the effect of erythropoietin in treatment of patients with renal anemia during hemodialysis treatment
10.3760/cma.j.issn.1008-6706.2011.24.020
- VernacularTitle:左卡尼汀对促红细胞生成素治疗血液透析患者肾性贫血疗效的影响
- Author:
Cui YAN
- Publication Type:Journal Article
- Keywords:
L-carnitine;
Erythropoietin;
Hemodialysis;
Anemia,renal
- From:
Chinese Journal of Primary Medicine and Pharmacy
2011;18(24):3354-3355
- CountryChina
- Language:Chinese
-
Abstract:
ObjectiveTo explore the influence of L-carnitine on the effect of erythropoietin in treatment of patients with renal anemia during hemodialysis treatment.Methods40 uremic patients with chronic renal failure underwent bemodialysis(HD) in were randomly divided into treatment group and control group,20 cases each.Control group was given EPO 9000u/week subcutaneous injection in the blood after dialysis,while regular oral iron,folic acid.Treatment group on the basis of the control group to 1.0g L-carnitine added 20ml 0.9％ sodium chloride injection intravenously 3 ～ 5 min,2 times per week.Both groups were treated for 3 months.Before treatment and after 4 weeks and 3 months treatment.The hemoglobin(Hb),hematocrit (Hct),serum ferritin (SF),serum thyroxine(iPHT) and compared.ResultsAfter 4 weeks of treatment,Hb,Hct levels increased compared with before treatment( all P ＜0.05).Hb after 3 months compared with the two groups before treatment were significantly higher(all P ＜0.05),and Hb increase of the treatment group significantly higher than the control group ( P ＜ 0.01).ConclusionL-carnitine could improve the treatment of erythropoietin in hemodialysis patients with renal anemia.
