Clinical observation on trimetazidine in treatment of chronic heart failure
10.3760/cma.j.issn.1008-6706.2011.23.019
- VernacularTitle:曲美他嗪治疗慢性心力衰竭疗效观察
- Author:
Xiang CHEN
;
Youming TUO
- Publication Type:Journal Article
- Keywords:
Heart failure,congestive;
Heart function;
Trimetazidine
- From:
Chinese Journal of Primary Medicine and Pharmacy
2011;18(23):3203-3204
- CountryChina
- Language:Chinese
-
Abstract:
Objective To explore the clinical effect of chlorpromazine(TMZ)in treatment of chronic heart failure(CHF).Methods 70 patients with CHF were randomly divided into control group and treatment group 35 cases in each gronp,control group was given conventional treatment,treatment group on the basis of additional application TMZ,20mg/times,3 times/d.8 weeks after the observation and comparison of two groups of cardiac function in improving the situation.Results Treatment group before the treatment of LVEF(38.0 ± 2.4)％ After treatment,LVEF(48.0 ±2.3)％ ;control group before treatment LVEF(38.2 ±2.2)％ after treatment,LVEF(42.0 t2.5)％ ;Twosets of treatment LVEFdifference statistically significant(t =6.9419,2.8482,allP ＜ 0.05); Treatment group compared with control groups after treatment improve even more obvious(t =4.3147,P ＜0.05)o Control groups and then hospitalized 10 cases(28.5％),the treatment group hospitalization 3 cases(8.5％),both groups rate difference statistically significant(x2 =4.629,P ＜0.05).Both groups were no deaths,no serious adverse effects.Conclusion General against heart failure therapy on the basis of the combined with TMZ could significantly improve the cardiac function of patients with chronic heart failure,reducing hospitalization rates.
